Merional

merional

General

Highly Purified Human Menopausal Gonadotrophin (HMG) for intramuscular and subcutaneous injection

Composition

1 vial of active ingredient contains: Active ingredient: Human Follicle Stimulating Hormone (FSH) 75 or 150 I.U.;

Human Luteinizing Hormone (LH) 75 or 150 I.U.

Indications

Stimulation of follicle maturation in infertile women.

a) Simple follicular stimulation

Hypo-and normo-gonadotropic an ovulation either with or without menstrual disorders; luteal insufficiency. In patients partially or completely unresponsive to a treatment with clomiphene

b) Multiple follicular stimulation.

In patients participating in a medically assisted reproduction program (IVF-ET, GIFT).

Dosage Administration

Merional is administered by intramuscular or subcutaneous injection.

Induction of ovulation: induce ovulation with an injection of human chorionic gonadotrophin (HCG) to bring a single Graaf follicle to maturation

These two treatment schemes are followed:

Scheme 1: Daily administration: The first injection of 1 vial of Merional 75 I.U. i.m. or s.c. should be given on the 4th / 5th day following a spontaneous menstruation or an induced bleeding. The treatment at a daily dose of 1 vial of Merional 75 I.U. should last for 7 to 12 days maximum, or until an adequate follicular maturation is obtained. If the desired result is not obtained, the treatment can be discontinued or pursued at a dose of 2 vials/day (= 150 I.U. of Merional). If, on the contrary, oestrogen plasma levels increase too fast

(> 100% in 2-3 days), the dosage of Merional must be reduced. 24 to 48 hours after the last injection of Merional, a single dose of 5,000 to 10,000 I.U. of HCG i.m. can be administered.

Scheme 2:

Administration every 2 days. In this treatment protocol, Merional is administered every other day.

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